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hyal 4  (Bio-Techne corporation)


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    Bio-Techne corporation hyal 4
    Hyal 4, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hyal 4/product/Bio-Techne corporation
    Average 94 stars, based on 2 article reviews
    hyal 4 - by Bioz Stars, 2026-03
    94/100 stars

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    A - D: Transcript levels of hyaluronidase gene family members in bladder tissues. Normal bladder: NBL (n=31); low-grade BC: LG (n=7); high-grade non-muscle invasive BC: HG NMIBC (n=6); HG MIBC (n=39). (A): HYAL-2, HYAL-3, PH20; (B): <t>HYAL-4</t> (C): HYAL-4 Wt; (D): V1. E: V1 levels of HG MIBC specimens further stratified by clinical outcome (metastasis and CSS). Data: Mean ± SEM. P-values two-tailed; Mann-Whitney U test. F and G: Kaplan-Meier plot showing risk-stratification of the cohort by V1 mRNA levels for metastasis and CSS.
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    A - D: Transcript levels of hyaluronidase gene family members in bladder tissues. Normal bladder: NBL (n=31); low-grade BC: LG (n=7); high-grade non-muscle invasive BC: HG NMIBC (n=6); HG MIBC (n=39). (A): HYAL-2, HYAL-3, PH20; (B): HYAL-4 (C): HYAL-4 Wt; (D): V1. E: V1 levels of HG MIBC specimens further stratified by clinical outcome (metastasis and CSS). Data: Mean ± SEM. P-values two-tailed; Mann-Whitney U test. F and G: Kaplan-Meier plot showing risk-stratification of the cohort by V1 mRNA levels for metastasis and CSS.

    Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

    Article Title: A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Bladder Cancer Patients.

    doi: 10.1158/1078-0432.CCR-19-2912

    Figure Lengend Snippet: A - D: Transcript levels of hyaluronidase gene family members in bladder tissues. Normal bladder: NBL (n=31); low-grade BC: LG (n=7); high-grade non-muscle invasive BC: HG NMIBC (n=6); HG MIBC (n=39). (A): HYAL-2, HYAL-3, PH20; (B): HYAL-4 (C): HYAL-4 Wt; (D): V1. E: V1 levels of HG MIBC specimens further stratified by clinical outcome (metastasis and CSS). Data: Mean ± SEM. P-values two-tailed; Mann-Whitney U test. F and G: Kaplan-Meier plot showing risk-stratification of the cohort by V1 mRNA levels for metastasis and CSS.

    Article Snippet: HYAL-4 shRNA transfectants: HYAL-4 shRNA constructs were purchased from Origene.

    Techniques: Two Tailed Test, MANN-WHITNEY

    A: Immunoblot analysis of bladder tissue extracts using anti-HYAL-4 antibody. B: Chase levels (U/mg protein) in bladder tissue extracts measured by Chase assay. C: HYAL-4 staining in representative NBL and BC tissues. Magnification: 400X. See Figure S2 for enlarged photos and quantification. D: Immunoblot anlaysis of cell lysates and CM of EV, Wt, and V1, Ctr, and HYAL-4 shRNA transfectants for indicated proteins; loading control: Actin. HYAL-4 peptide block: the peptide was added during incubation with the anti-HYAL-4 antibody. Note for A and D: In each blot, all sample lanes were run on the same gel with the same exposure time; a gap denotes those samples that were not contiguous within the gel. E: Chase activity (U) was measured in the CM of bladder cell transfectants (left panel) and in the CM of control (Ctr) and HYAL-4 shRNA transfectants (right panel). The activity was normalized to cell number. Data: Mean ± SEM; quadruplicate. F: Normalized Chase activity in the CM of HT1376 transfectants and in a high-grade bladder tumor tissue extract (HG-TBL) at indicated pH. Data: Mean ± SEM; quadruplicate. G: Chase activity in the CM of HT1376 V1 transfectants and a HG-TBL extract measured against different chondriotin sulfate substrates. Data: Mean ± SEM; quadruplicate.

    Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

    Article Title: A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Bladder Cancer Patients.

    doi: 10.1158/1078-0432.CCR-19-2912

    Figure Lengend Snippet: A: Immunoblot analysis of bladder tissue extracts using anti-HYAL-4 antibody. B: Chase levels (U/mg protein) in bladder tissue extracts measured by Chase assay. C: HYAL-4 staining in representative NBL and BC tissues. Magnification: 400X. See Figure S2 for enlarged photos and quantification. D: Immunoblot anlaysis of cell lysates and CM of EV, Wt, and V1, Ctr, and HYAL-4 shRNA transfectants for indicated proteins; loading control: Actin. HYAL-4 peptide block: the peptide was added during incubation with the anti-HYAL-4 antibody. Note for A and D: In each blot, all sample lanes were run on the same gel with the same exposure time; a gap denotes those samples that were not contiguous within the gel. E: Chase activity (U) was measured in the CM of bladder cell transfectants (left panel) and in the CM of control (Ctr) and HYAL-4 shRNA transfectants (right panel). The activity was normalized to cell number. Data: Mean ± SEM; quadruplicate. F: Normalized Chase activity in the CM of HT1376 transfectants and in a high-grade bladder tumor tissue extract (HG-TBL) at indicated pH. Data: Mean ± SEM; quadruplicate. G: Chase activity in the CM of HT1376 V1 transfectants and a HG-TBL extract measured against different chondriotin sulfate substrates. Data: Mean ± SEM; quadruplicate.

    Article Snippet: HYAL-4 shRNA transfectants: HYAL-4 shRNA constructs were purchased from Origene.

    Techniques: Western Blot, Staining, shRNA, Blocking Assay, Incubation, Activity Assay